Learning and teaching Mendelian genetics are central topics in school science. This study explored factors associated with the learning outcomes of Taiwanese junior high school students in an online inquiry learning environment. Research within face-to-face classroom settings had revealed that Asian students are more likely to be tutor-oriented and collectivistic learners. However, results of how these orientations affect learning in online environments are needed. In this analysis, seventh-grade students from Taiwan (N = 290) completed a genetics lesson using an Inquiry Learning Space (ILS) on the Go-Lab platform. Students were randomly assigned conditions in which support was provided either by general text or by an expert person in the form of a cartoon figure. In addition, students completed questionnaires assessing their cultural orientations, as well as their computer self-efficacy. Results revealed that the presence of a virtual expert did not influence students' learning outcomes. However, the extent to which students identified as collectivistic and their level of computer self-efficacy were positively associated with the learning outcomes. Students' computer self-efficacy was positively related to their behavioral intentions as well. These results illustrate the importance of Asian students' disciplined personality and computer self-efficacy for online inquiry-based learning.