Increased international attention paid to research-based education has resulted in various national initiatives to exploit research in education. However, this poses challenges for school professionals. Based on an ethnographic single case study in a Swedish educational setting, this article investigates how national policy on research-based education is realized at local school level from the perspective of principals. Theoretically, the study applies a policy enactment understanding, arguing that policy is put into action in original ways in various local settings. Through thematic analysis four interrelated main strategies deployed by the principals were identified: strategies facilitating durable structures, developing learning cultures, developing teachers' competencies, and strengthening leadership. The strategies demonstrate the complexities in policy enactment as it involves multiple embedded local processes and settings. Additionally, the study contributes to an understanding of how different interrelated national policies and initiatives intersect when enacted at school level.