The present study aims to determine if the successful implementation of a blended learning methodology is more dependent on the course subject matter or on the teacher. Using the Evaluation Scale on the Influence of Course Subject and Teachers on B-learning, we analyzed five factors: Expectations, Web Tools 2.0, Feedback, Cooperative/collaborative Learning, and Social Relations. The results show that student expectations and cooperative/collaborative learning are dependent on the course subject matter while all five factors crucially depend on the role of the teacher. We concluded that teachers have a much greater influence than the course subject on the successful implementation of an effective blended learning model.