Introduction: The increase and concern that cyberbullying raises within the educational community show the need for evidence-based programs that allow preventing and intervening in this type of violence. The objective of this study was to analyze the efficacy of the Prev@cib 2.0 program in reducing cyberbullying and promoting helping behaviors and perception of help from the teacher. Method: A repeated measures pre-post-test design was used with a control group and an intervention group (in the latter, the Prev@cib program was implemented for 4 months). 580 adolescents between 12 and 17 years old (M =13.52, SD =1.27) participated in the study. Results: The results showed a significant decrease in cybervictimization and cyberaggression, and an increase in helping behaviors and perception of help from the teacher after the program in the intervention group, compared to the control group. Discussion or Conclusion: These results confirm the efficacy of the Prev@cib 2.0 program to prevent cyberbullying in adolescence. Furthermore, the importance of the involvement of the entire educational community to prevent this problem is showed.