The characteristics of and risk factors associated with binge drinking among South Korean and American adolescents were identified in this study. Data on adolescents in the 9th to 12th grades were extracted from two nationwide data sets: the Korea Youth Risk Behavior Web-based Survey System and the U.S. Youth Risk Behavior Surveillance System. Binge drinking was observed among 16% of American adolescents during the past month and among 11.6% of Korean adolescents during the past year. For adolescents from both countries, the following seven similar significant factors were associated with binge drinking: female gender, higher grade, fighting-related injury experience, current cigarette smoking, preteen smoking initiation, participation in team sports, and depression. Among Korean adolescents, higher or lower level of academic achievement and inadequate sleep were additional unique factors associated with binge drinking. These results could be useful for developing interventions for adolescents engaging in binge drinking in both countries.