The Self-Determined Learning Model of Instruction (SDLMI) has been identified as an evidence-based practice to support educators to teach students with disabilities to engage in self-regulated learning leading to enhanced self-determination, attainment of academic and functional goals, and enhanced access to the general education curriculum. This article reports the results of a meta-analysis of the efficacy of applying the SDLMI as an intervention to enhance access to the general education curriculum or transition-related outcomes. Fifteen single-subject research studies examining the efficacy of the SDLMI as an intervention for students with disabilities were synthesized and the impact was analyzed across intervention and participants' characteristics using the percentage of non-overlapping data (PND) metric. The results of this analysis add to the evidence for the efficacy of implementing the SDLMI as an intervention to promote academic and functional goal attainment for students with disabilities. Implications and directions for future research are discussed.