Background: This article emerged from a larger qualitative study, which revealed that children continue to be exposed to a complex range of risk factors with devastating consequences for their well-being. Gaps in services further hinder their development. The study concluded that there is a need for multidisciplinary teams to implement an early childhood home-visiting programme, and that such a programme would hold many potential benefits for the young and vulnerable children. Aim: This article presents a set of guidelines that can be used to support good outcomes for an early childhood home-visiting programme for vulnerable children aged 0-2 years. Setting: The study is set in the Eastern Cape province of South Africa. Methods: The guidelines were developed over three phases of the study, which used an intervention research design. Results: The guidelines emerged as a number of practice principles and include: engagement and advocacy; the recruitment of a multidisciplinary workforce; training of the home-visiting workforce; implementation of the programme; and monitoring and evaluation of the programme. Conclusion: The article suggests that the guidelines hold promise for both supporting the well-being of vulnerable children and shaping a programme that is preventative, focussed on early intervention, and both multidisciplinary and transdisciplinary in nature. Contribution: The guidelines are intended as a support to those working in the fields of both early childhood and vulnerable children, and can be used alongside the existing services.