The Fourth Industrial Revolution (4IR) has been the subject of discussion, and in most cases, it has been seen as a threat to jobs and conventional methods of performing certain activities. As a result, concerns over the preparation of the South African educational systems for the 4IR have been raised. Many industries still lack an advanced understanding of the 4IR, but the concept is already gaining ground in various economic areas. Thus, academics, business professionals, and legislators are paying closer attention to 4IR. The researchers were inspired to examine how the 4IR techniques were applied in South African Higher Education Institutions (HEIs) to advance the growth and development of teaching and learning by this noticeable knowledge gap. To investigate how 4IR technologies improve the growth and development of teaching and learning in South African HEIs, this study used a systematic literature review (SLR) methodology. A search procedure, research keywords, inclusion and exclusion criteria, and quality assessments of chosen literature were used in conjunction with the SLR approach. Twenty-one documents were retained after selecting them according to their theme and outline objectives. This study found that some South African HEIs have successfully adopted 4IR virtual and contact instruction technologies. The research further found that academics and support staff utilized various 4IR tools. This is done through a virtual or hybrid classroom, artificial intelligence, and the Internet of Things (IoT), with different devices to send students messages, schedule Zoom classes, and provide feedback and educational resources. However, the study presented recommendations that academics can use to ensure that the 4IR is effectively integrated to support the expansion and improvement of teaching and learning in HEIs. Future research directions were suggested, and the study came to the conclusion that South Africa could change the direction of the management of the education sector by implementing various 4IR tools in HEIs.