Given the flexibility and ubiquity brought about by mobile learning (m-learning), many learning institutions have adopted m-learning to ensure efficiency and effectiveness in teaching and learning. Catalysed by COVID-19 protocols such as social distancing and lockdowns, m-learning is gaining a lot of ground in Africa. As a result, several m-learning deployment models and strategies have emerged. Although many studies have been conducted in this domain, there are still no global models and best practices that guide implementation of m-learning especially in resource-constrained contexts. This study employs a systematic review and interpretive approach to collate the key body of knowledge in m-learning design and implementation over the past 10 years in sub-Saharan African (SSA) countries. Comparison with m-learning practice in the developed world, as a barometer to ascertain the advancement of m-learning practice in the developing world, with a particular focus on sub-Saharan Africa was also undertaken. The results show that m-learning research is predominantly undertaken in South Africa and Nigeria with only a few other countries engaging in such research. However, most of the studies were not grounded on solid theoretical frameworks and empirical findings. Moreover, this study found that the Technology Acceptance Model is the most used theoretical framework. Most studies on m-learning have relied on surveys as the most preferred data collection tool. These findings contribute towards knowledge creation at levels of theory and practice by highlighting the extant knowledge, and gaps that could inform future m-learning research.