This study examined the relationship between students' satisfaction in the newly developed Learning Management System "Acadox", and their perceptions of its usefulness, and ease of use. The study used a descriptive correlational design to examine the relationships among variables, as they exist in their natural settings. To measure students' satisfaction in Acadox, perceptions of usefulness, and perceptions of ease of use of Acadox, a web-based survey was developed be the researcher. Data were collected from seventy-five students enrolled in courses that used Acadox as a learning management system in the Middle East region, namely, Egypt and Saudi Arabia. The findings of this study revealed that students' perceptions of ease of use, and perceptions of usefulness were significant predictors of satisfaction in Acadox. The findings of this study are consistent with the Technology Acceptance Model (TAM), which indicates that one's perceptions of ease of use, and perceptions of usefulness of the new technology are the key factors that determine whether user will accept or not the new technology.