The relevance of the investigated problem is conditioned by the fact that one of the negative factors, which prevent favorable socialization and successful personal-professional development of students, is the tendency of youth to be prone to addiction the formation of which is affected by various mental states. The paper is aimed to explore the characteristics of emotional and estimative mental states of the students who are prone to alcohol and drug dependencies. The leading methods to the study of this problem are psychological testing and analysis of statistically processed data obtained. In the course of empirical research it is found that students with a high propensity to both alcohol and drug addiction possess the emotional perception of self-image is significantly more negative than the students with low propensity. Their dominant mental negative emotional and estimative state that contributes to the high level of addiction to psycho-active substances is a condition which is caused by the insufficient adequacy of self-esteem and the failure of themselves. These article data can be used to improve the psycho-pedagogical activity on reducing the level of addiction to substance abuse among students, to develop effective prevention programs.