The pervasive nature of online learning worldwide necessitates the creation, administration, and improvement of quality assurance mechanisms for higher education institutions. This article delineates a number of principles regarding features of high quality online learning systems and principles related to assessment of student learning, teacher quality measurements, and course and program evaluations. An overview of select world-leading online learning universities, leading standards for online learning systems, some important players providing services regarding online learning and quality assurance, and an extensive further reading list are provided.