As a non-selective neighborhood high school in the School District of Philadelphia, B21's mission is to empower networks of learners to connect with their passions and build agency to impact their world. Building 21 is organized into studios, workshops, and advisories. Core studios engage students in project-based learning. Blended learning modules and focused skill development are incorporated into workshops. Students are grouped into an advisory to create connections, build a sense of identity, and support personalized pathways of learning at the school. The two-page grantee profiles from Next Generation Learning Challenges (NGLC) provide factual information about the secondary school and postsecondary degree program designs awarded grants under NGLC's third and fourth waves of funding, which focused on two areas, "Breakthrough Models for College Readiness" and "Breakthrough Models for College Completion." The profiles describe what makes each model "breakthrough" and express both visually and through at-a-glance details the academic and organizational models, student demographics, hardware and software choices, and contact info. These profiles serve to illustrate the innovations of these new blended and online models, with practical details of interest to those starting a new school or degree program.