The present paper explores some important social factors responsible for the low motivation of girls for primary education in the slum areas of Karachi, Pakistan. The objective of the study was to identify the challenges and social factors responsible for the low motivation of girls for education in the slums of Karachi. The study was qualitative in nature. All the teachers, school heads and female students of government girls primary schools in slums areas from Kamari, Malir, Lyari, Baldia and Gadap towns of Karachi were included as the population. Fifty teachers, twentyfive school heads, and fifty students were selected as a sample on the basis of purposive sampling. The information was collected through interviews, focus group discussions, observations and informal conversations. To analyze the qualitative data of interviews, focus group discussions and field notes, "Constant Comparative Method" was used. The researcher conducted thematic analysis approach to analyze the qualitative data. The analysis revealed that the socio-economic status of the parents, socio-cultural barriers and child labour are the main reasons for the low motivation of education for girls in the slum areas of Karachi. Policy recommendations based on the findings have further been discussed in the study.