The Game Changer is an interrupted case study that traces the football career of Anthony "Tony Tonka Truck" Williams and the types of brain trauma that he suffers from playing football, from junior league level through high school, college, and his draft into the pros. To be successful during this case, readers will have to be familiar with the signs, symptoms, epidemiology, and ramifications of concussions, Second Impact Syndrome (SIS), and Chronic Traumatic Encephalopathy (CTE). Students will analyze and compare the differences between these three types of brain trauma and predict the outcome of Anthony's health based on symptoms and events given in each part. This case can be completed during one class session and is appropriate for upper level undergraduate and graduate courses in neuroscience, sports-related rehabilitation, physical education, and allied health professions including but not limited to: Sports Medicine, Principles of Neuroscience, Principles of Rehabilitation, Gross Anatomy, and Anatomy and Physiology.