Innovation in education is vital for responding to emerging challenges, such as the COVID-19 pandemic, and for building progress on longstanding challenges in schools. The infusion of substantial, highly flexible pots of federal relief dollars created an opportunity to pilot new programs and initiatives. Many states and districts opted to invest resources in traditional K-12 expenses, such as increasing staff capacity or updating facilities. However, states are also using the funds to spark new initiatives that otherwise may not have been possible and can be replicated across the country. This Policy Guide presents six strategies along with state examples to assist in planning, designing, implementing, and sustaining innovative services and programs. In addition to these strategies, other researchers have developed models for change that put forward other unique approaches, such as allowing for locally driven variation, providing human capital support for ongoing technical assistance and tolerating small-scale risk. The end goal of using these approaches is to design innovative policies that endure and improve long-term student outcomes.