The purpose of the study is to find out the effects of school location and teachers' quality on students performance in Business Studies Examination in public secondary schools in Sapele Local Government Area of Delta State Nigeria. Four research questions guided the study, and the expost facto research design was used for the study. The population of the study was 2579 students that sat for Business Studies in the Basic Education Certificate Examination in public secondary schools in Sapele Local Government Area of Delta State for 2016/2017 Academic Session. No sampling was done population was used as sample for the study, as well, no instrument was develop for data collection, data were collected on request from Ministry of Primary and Basic Education, Sapele Field Office. Data collected were analysed using simple frequency count and percentage for the research questions. The results show that location does not have significant effects on students' performance. Also, the findings revealed that qualification of teacher has significant effects on students' performance. Based on the findings of this study, it was concluded that school location does not have significant effects on students' performance in Business Studies examination in secondary schools in Delta State. As well, teachers' qualification has significant effects on students' performance in Business Studies examination in secondary schools in Delta State. Hence, it was recommended amongst others that Delta State Ministry of Basic and Secondary Education should employ qualified teachers to teach Business Studies in secondary schools in Delta State.