The study investigated the application of education information management support tools in the promotion of teaching/learning and management of students' performance in federal universities in the South-South zone of Nigeria. Two research questions and two null hypotheses guided the study. The study adopted a descriptive survey design. The population of this study comprised all the 6 federal universities in the South-South region of Nigeria with 960 senior ICT academic staff and 210 senior ICT non academic staff. The sample of this study consisted of 234 staff made of 192 academic and 42 non-academic staff that was randomly drawn from the 6 federal universities in the south-south region of Nigeria. The sample constitutes 20% of the total population. Self structured instrument titled Education Management Information Support Tools in the Management of Students Performance Questionnaire (EMISTMSPQ). The instrument was structured after the modified four point rating scales. Face and content validities were ensured by experts in the area of information communication and technology. A reliability coefficient of 0.81 was established using cronbach alpha reliability method. Mean was used to answer the research questions while z-test was used to answer the null hypotheses. It was found out among others that teaching and learning can be enhanced through bulletin board, complementing course contents, posting assignments to students online, posting students' grades, encouraging interaction and collaboration, facilitating researches, using blog postings by teachers to solve problems and arouse thinking skill, providing forum where teachers and students meet to interact on-line and so on. It was recommended that the universities in the south-south region should brace up with the best and current global practices by completely integrating university management into the mainstream of EMI-based scheme of doing things.