The authors administered the National College Health Risk Behavior Survey to 1,219 college students who were attending a historically Black college located in New York City. They assessed the US-born Black students and Black students who emigrated to the United States for differences in risky sexual behaviors, risky dietary behaviors, and physical inactivity. They used bivariate and multiple regression analyses to analyze the data and observed significant differences between the US-born and non-US-born students in the behavioral domains of risky sexual behaviors (p = 0.003), risky dietary behaviors (p = 0.001), and physical inactivity (p = 0.010). They conclude that immigration is associated with health protective behavior in the domains of sexual behavior and physical activity among the Black college students attending this particular institution. However, in the domain of dietary intake, immigration status was associated with increased risk in these Black college students. (Contains 5 tables.)