The Collaborative Minnesota Partnerships to Advance Student Success (COMPASS), a statewide education system designed to support schools' and districts' efforts to accelerate student learning, offers professional development opportunities with various levels of support. Through COMPASS school districts and charter schools are provided a variety of resources, evidence-based practices, and facilitated guidance to support schools in areas of Literacy, Math, and School Climate and Mental Health using the Minnesota Multi-Tiered System of Supports (MnMTSS) continuous improvement framework. As part of the federally-funded Region 10 Comprehensive Center (R10CC), the Center for Applied Research and Educational Improvement (CAREI) at the University of Minnesota has collaborated with the Minnesota Department of Education (MDE) to develop a wealth of written resources to support implementation of MnMTSS across Minnesota schools and districts. This brief summarizes what was learned from three Minnesota school districts who participated in COMPASS cohort learning experiences. The report introduces each district and describes how their teams engaged in the cohort courses, how their participation impacted local MnMTSS development and implementation, and what lessons they learned along the way.