This document introduces the issue of self-protection as the Minnesota 4-H Youth Development response to self-destructive behavior among adolescents. It presents findings from a statewide survey of over 36,000 secondary school students using the Minnesota Adolescent Health Survey. Responses are given in the areas of health, school attitudes, sexual activity, worries and concerns, substance abuse, mental health, body image and eating behavior, adults and family relationships, abuse, and help seeking. Health programs sponsored by the Minnesota 4-H and guided by the survey findings are described. The prevention theory used in the programs is explained, the need for youth involvement in the Self-Protection programs is stressed, and training for the adolescents is discussed. The need to start early and the importance of adult guidance are noted. Comprehensive, community-wide programs are briefly reviewed and Minnesota 4-H relations with state agencies and with universities and other health and youth organizations are described. Nine programs which were developed in the first phase of the Self-Protection program are described. The programs presented deal with issues of alcohol and drinking and driving; stress, depression, and suicide; sexuality; and violence in relationships. (NB)