Background: Cancer drug therapy is a high-volume, high-risk clinical encounter that requires close coordination across interprofessional clinical teams. Purpose: The Multi-Professional Oncology Safety and Simulation Training (MOSST) program, supported by the National Cancer Institute was launched in Fall 2018. The original workshop was conducted in person. As the COVID pandemic hit the program was transitioned to an on-line/distance simulation program. Method: The full day workshop was moved to an on-line platform using Zoom and the in-person simulations were re-developed as video simulations. We then evaluated learner outcomes identically in each modality using the evaluation metrics from our original workshop. Discussion: We found that the use an of online modality to deliver the MOSST workshop resulted in a high-quality educational experience for the learners and the educational outcomes were comparable.