A semester-long research project to synthesize unique compounds designed after published metalloprotease peptide inhibitors is presented. The research project encompasses a set of nine organic chemistry reactions traditionally taught in the second semester lab course, and the procedures are derived from scientific literature. The two principle goals of the course design are (1) to enhance student interest through the scientific applications of the research project and (2) to introduce students to a synthetic organic chemistry research experience to develop skills needed in this area. In addition to the exploratory synthesis of novel compounds, students read background review articles about metalloprotease inhibitors. The design of the project provides opportunity for collaboration over multiple years, between different courses within the university, and among different schools.