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Taylor, Elizabeth Vogel; Fortune, Jennifer A.; Drennan, Catherine L. – Biochemistry and Molecular Biology Education, 2010
Here, we present a six-session laboratory exercise designed to introduce students to standard biochemical techniques in the context of investigating a high impact research topic, acquired resistance to the cancer drug Gleevec. Students express a Gleevec-resistant mutant of the Abelson tyrosine kinase domain, the active domain of an oncogenic…
Descriptors: Cancer, Drug Therapy, Biochemistry, Laboratory Experiments