Through the collaboration of its members, the Business-Higher Education Forum (BHEF) launched the National Higher Education and Workforce Initiative (HEWI) to support business-higher education partnerships that co-design community college and university pathways to careers in fields critical to innovation and national security, as well as maximize work-based learning to increase transfers, degree attainment, and connections to living-wage jobs. This case study looks at how BHEF member, the University System of Maryland (USM), collaborated with businesses and government agencies to develop cybersecurity pathways on multiple campuses to build a diverse regional cybersecurity talent ecosystem that can address national security needs. The case study also provides recommendations for stakeholders in government, business, and higher education on developing an ecosystem for cybersecurity skills needs--or one that can serve as a model for other fields. It builds upon BHEF's work to create new undergraduate pathways in high-skill, high-demand fields. As part of HEWI, BHEF received a $400,000 grant from the Alfred P. Sloan Foundation in 2012 to work with USM and the Northrop Grumman Corporation on the development of undergraduate pathways in cybersecurity. In partnership with BHEF, USM pursued a coordinated, system-level effort to create new cybersecurity pathways that would attract diverse students, engage them in cutting-edge learning experiences, and encourage them to build their careers in the region. [This work was funded by the University System of Maryland and five of its campuses: Bowie State University, Towson University, University of Maryland, Baltimore County, University of Maryland, College Park, and University of Maryland University College.]