People with epilepsy may face a number of complex and interacting problems and barriers related to employment. Understanding these barriers is an important step toward implementing effective rehabilitation interventions. This article explores the factors that predicted employment status among a community-based sample of adults with epilepsy. Data for the analysis were collected from 146 adults with epilepsy through Epilepsy Foundation chapters in Wisconsin, Kentucky, and Ohio. Several demographic and epilepsy-related variables were analyzed to explore the determinants of employment status. Results of a binary logistic regression analysis suggest that gender, number of antiepilepsy medications used, seizure frequency, and reported interference in daily functioning created by seizures were the best predictors of employment. Additional analyses suggested that the possession of a driver's license was also associated with employment status. The results are discussed in terms of their implications for rehabilitation-based intervention. (Contains 3 tables.)