This comparative study examined the academic success rates of online graduate nursing students by comparing final grades to the on-campus cohort of graduate nursing students prior to the program transitioning online. Analysis was conducted by identifying and comparing final course grades in 4 required Master of Science in Nursing (MSN) courses over a period of 6 years. Five key themes related to online student success are discussed, including the need for graduate nursing MSN programs to transition to an online format, barriers to online learning, comprehensive program evaluation of an online degree program, online student retention approaches, and exploration of whether online students have been shown to be as academically successful as on-campus students. Results reveal that both cohorts of course delivery modes yield academically successful MSN students and both course delivery modes are providing the MSN program with almost equal pass rates by the students taking the required core courses.