The case study profiles the Aiku Centre at Ca' Foscari University in Venice, Italy, suggesting its role as a contemporary higher education institution committed to fulfilling its 'third mission' and addressing broader societal challenges. The Aiku Centre integrates artistic interventions with academic research and organizational practices, fostering interdisciplinary collaboration and innovation. Projects like 'Artificare' and the SMATH initiative exemplify the Centre's approach to combining art, sustainability, and business for societal progress, emphasizing the transformative potential of artistic interventions in environmental and social challenges.