One of the points of science learning is to extend students' competence, counting problem-solving and analytical thinking. Conditions within the field appear that most students encounter trouble in fathoming relevant issues including the application of science concepts in real-world circumstances. This condition appears the require for compelling learning models and approaches to overcome the holes. This condition is additionally the premise for creating a problem-based learning (PBL) show based on Science Education for Sustainable Development (SESD). Research questions were investigated using a quasi-experimental pre-test/post-test design. This design is used to compare the learning outcomes achieved in the treatment class with those of the control class. The subjects of this study consisted of the students of class VIII of SMP Negeri X Ponorogo. Meanwhile, students of VIII class F, which is the experimental class, and students of class VIII D, which is the control class, were used as the research sample. From the t-test using independent sample test it is known that he use of PBL model and SESD approach has no significant impact on students' problem-solving skills but there is a significant impact on students' analytical thinking skills. From the MANOVA test we know that the overall significance values of Pillai's Trasce, Wilks' Lambda, Hotelling's Trace and Roy's Maximum Root are 0,000 < 0,05, so the use of PBL model and SESD approach has a significant impact on the 8th grade student's ability both to solve contextual problems and analytical thinking on the subject of food and digestive system.