The limitation of face-to-face meetings imposed by the COVID-19 pandemic has encouraged education environment to develop learning models with technology which can be integrated with Electronic-Problem-Based Learning (E-PBL). The study revealed whether the E-PBL Model, significantly affected (1) motivation, (2) learning interest, (3) achievement, (4) motivation toward students' achievement, (5) learning interest toward students' achievement and (6) motivation toward students' learning interest in the entrepreneurship course. This study was quantitative, employing E-PBL software. The subjects of the study were 129 students of Economics Education department at STKIP PGRI Jombang, Indonesia who were taking entrepreneurship course by implementing E-PBL in academic year 2019/2020. Data were collected using observation, interviews, and questionnaires and analyzed using Path Analysis. The E-PBL Model significantly affected motivation, learning interest, achievement, motivation toward students' achievement, learning interest toward students' achievement and motivation toward students' learning interest in the entrepreneurship course It is recommended that teachers implement the E-PBL Model because it can increase learning motivation and interest that finally increase learning achievement.