The study examines the effects of work-from-home (WFH) on working mothers in India, characterized by a patriarchal mindset, during the COVID-19 pandemic. A survey involving 560 mothers from various sectors, all utilizing WFH due to pandemic measures, was conducted. A moderated mediated model was analyzed in the quantitative study using structural equation modeling. The results showed the absence of domestic help and family work guilt affected the job satisfaction of working mothers. The results showed that the overall dual-stage moderated mediation index from home demands (HDs) to job satisfaction via family-work conflict was significant. In addition, the first stage (HDs × absence of domestic help family-work conflict) and second stage (family-work conflict × family-work guilt job satisfaction) moderations were significant. This article also outlines the limitations of the current work and presents future scope for research.