COVID-19 is a wide-reaching health emergency which makes the globe to a standstill with supreme and unexpected impact in our life. The present study is focused on the mental health, stress and academic anxiety among students of higher education. This study was conducted to know the level of mental health stress and academic anxiety of the higher education students during this pandemic virus period. The sample consists of 883 various higher education students from all over Tamil Nadu, India. An online survey was conducted using a questionnaire, and snowball sampling technique has been used for the selection of sample. The data were analysed using a 't' test and percentile of the response. The major findings of the study revealed that there is a significant difference in the COVID-19 crisis knowledge and adaptations of the pandemic situation of the higher education students of India with respect to sex, course of studying, discipline within its higher education institutions.