The present study used hierarchical linear modeling to examine predictors of students' emotional and behavioral difficulties in preschool classrooms. Specifically, the study examined (a) the link between teachers' perceptions of their own emotional intelligence and students' emotional and behavioral difficulties, (b) the link between teachers' perceptions of students' social skills and emotional and behavioral difficulties, and (c) how teachers' perceptions of their own emotional intelligence were related differentially to their perceptions of students' emotional and behavioral difficulties based on students' social skills. Participants were 92 preschool teachers and 238 students from 52 state schools in central Greece. Research Findings: Results indicated that higher scores for teachers' perceptions of emotional intelligence and students' social skills were related to lower scores for teachers' perceptions of students' emotional and behavioral difficulties. Teachers' perceptions of emotional intelligence were important in predicting students' emotional and behavioral difficulties, especially in the case of students' lack of social skills. Practice or Policy: This study provides empirical support for the predictors of students' emotional and behavioral difficulties by taking into consideration both teachers' perceptions of emotional intelligence and students' social skills, thus suggesting new insights into the interpretation of emotional and behavioral difficulties in preschool.