Perfectionism is a multidimensional personality trait whose facets differentially relate to indicators of psychological functioning, such as global self-esteem. There has been some theoretical disagreement whether perfectionism affects global self-esteem, or vice versa. This question merits renewed attention due to increasing efforts to prevent the development of maladaptive perfectionism facets in adolescents. In addition, recent research has indicated a role of self-esteem for predicting personality development. This study aimed to clarify the longitudinal relations of multidimensional perfectionism and global self-esteem. A sample of 707 early adolescents participated in two measurement points two years apart. Global self-esteem positively predicted personal standards, negatively predicted doubts about actions, and did not predict concern over mistakes beyond baseline. Perfectionism facets did not longitudinally predict global self-esteem. These findings provide the first evidence for a role of global self-esteem in perfectionism development. Addressing early adolescents' self-esteem may aid in preventing the development of maladaptive perfectionism facets.