The Council for Adult and Experiential Learning (CAEL) developed the Adult Learner Leaders for Institutional Effectiveness (ALLIES) Framework to help guide institutional policies and practices in their work to support adult learners. This document begins by describing the Framework's series of planning and operational domains through which institutions can more effectively support today's adult learners. In the initial levels, the focus is on building a strong foundation through domains that are part of data-driven planning and organizational capacity building, including attention to policy and governance structures that better support adult learners. On that foundation are then built the program- and service-focused domains that address the adult learner's direct student experience. The report concludes with a vision for how institutions can use the new framework and change management process, along with guiding questions for institutional implementation. Appended are summaries of high-performing programs examined in this report. [For the companion report, "'It's a Little Stressful When I Think of It…': Results of a National Survey and Interviews with Never-Enrolled Adults on the Factors That Drive Them to Consider Postsecondary Education and the Barriers to Enrollment. A CAEL Research Brief," see ED624379.]