This implementation research report describes the local programs, home visiting staff, and families who participated in the Mother and Infant Home Visiting Program Evaluation (MIHOPE), a national evaluation of the federal Maternal, Infant, and Early Childhood Home Visiting (MIECHV) program launched in 2011. This national evaluation is systematically examining how program features and implementation systems are associated with services delivered and impacts across four of the home visiting models designated as evidence-based by the U.S. Department of Health and Human Services: Early Head Start -- Home-based option, Healthy Families America, Nurse-Family Partnership, and Parents as Teachers. To provide reliable estimates of the effects of home visiting programs, the MIHOPE team randomly assigned families who were interested in and eligible for a MIECHV-funded local program participating in MIHOPE, and who consented to be in the study, to either the MIECHV-funded local program or a control group that was referred to other appropriate services in the community. The entire period of implementation research data collection lasted from September 2012 to June 2016. Implementation research activities included family surveys and observations of families' home and external environments at baseline, family service logs, observations of home visitor-family interactions, staff surveys, semi-structured qualitative interviews with home visitors, training logs, supervision logs, inventories of community services, surveys and interviews with evidence-based model developers, and reviews of local program and evidence-based model documents. Key findings include: (1) The MIECHV-funded local programs served families in disadvantaged communities with high levels of risk; (2) Similar to prior research, families in MIHOPE participated in home visiting for eight months on average, which is less than expected by the four evidence-based models in the study; (3) Local programs focused on improving parenting and child development outcomes, areas historically emphasized by all four of the evidence-based models; and (4) Services related to sensitive topics were tailored to family needs.