In 2005-2006, students with disabilities comprised 9 percent of the student population in the United States, and English language learners comprised about 10 percent. Many of these students spend a majority of their time in the general classroom setting in elementary and secondary schools. Most teachers are initially trained through teacher preparation programs at institutions of higher education. GAO was asked to examine (1) the extent to which teacher preparation programs require preparation for general classroom teachers to instruct these student subgroups; (2) the role selected states play in preparing general classroom teachers to instruct these student subgroups; and (3) funding and other assistance provided by the U.S. Department of Education (Education) to help general classroom teachers instruct these student subgroups. To address these issues, GAO conducted a nationally representative survey of teacher preparation programs and interviewed officials from state and local educational agencies in four states and Education. GAO recommends that the Secretary of Education develop and implement a mechanism to ensure more systematic coordination among program offices that oversee assistance that can help general classroom teachers to instruct these student subgroups. Education agreed that coordination is beneficial and will explore the benefits of creating such a mechanism. Appended are: (1) Objectives, Scope, and Methodology; (2) Education-Funded Regional Research and Technical Assistance Providers GAO Interviewed; (3) Education-Funded National Research and Technical Assistance Providers GAO Interviewed; (4) Comments from the U.S. Department of Education; and (5) GAO Contact and Staff Acknowledgments. (Contains 5 tables and 13 figures.)