Background: Caregivers of stroke survivors need trusted information on stroke prevention, rehabilitation, and self-care. Purpose: Develop and evaluate the English and Spanish-language RESCUE stroke caregiver websites and conduct a promotional campaign to enhance their reach. Methods: We developed websites by partnering with organizations and using health communication guidelines for consumer-oriented, age-appropriate, and culturally sensitive materials. Healthcare provider focus groups and caregiver interviews were conducted to obtain feedback. Websites were refined and assessed for usability through "think aloud" testing and surveys. We implemented a multi-faceted promotional campaign and measured website visits. Results: Providers (N = 32) and caregivers (N = 47) responded positively to the websites, describing them as comprehensive and appropriate. Usability testing indicated the websites were appealing, informative, and organized. Caregivers with minimal computer skills had difficulty navigating the websites. The websites received 218,529 visits over 2 years. Promotional activities corresponded with increases in website visits. Discussion: Involving end-users and collaborating with partners enhances the accessibility and relevance of online health resources. Multi-faceted promotional efforts and key stakeholder partnerships are required to enhance and sustain the reach of online caregiving resources. Translation to Health Education Practice: The RESCUE websites are comprehensive public sources of evidence-based materials to support stroke patients and their caregivers.