The present study aims to examine effective measures to enhance the effects of entrepreneurship education (EE) on university students' entrepreneurial intention (EI) through entrepreneurial self-efficacy (ESE) and grit. The survey used a convenient sample of 758 tourism and hotel management students in China. SPSS macro program PROCESS (Model 4) was used to test the mediating effect, and PROCESS (Model 7) was further used to verify the moderated mediation model. The results indicated that: (1) there was statistically significant and positive relationship among EE, ESE, grit, and EI among tourism and hotel management students; (2) EE significantly and positively predicted EI; (3) ESE played a partial mediating role in the link between EE and EI; (4) grit moderated the indirect effect of EE on students' EI via their ESE. EE is a significant predictor of EI of tourism and hotel management students. Particularly, to improve the influence of EE, entrepreneurial policy makers should design incentive policies that ensure that universities provide EE across various majors. Also, educators should create a supportive and effective education environment so as to improve students' ESE and grit.