Objective: The constant deterioration of the physical fitness of college students has been a popular topic in China, thus this research analyzes the potential health risk of inadequate physical activity among college students. Participants/methods: During the national student fitness test (NSFT) in 2012, 1500 students from Tsinghua University were recruited and asked to complete the international physical activity questionnaire. Finally, 1414 (94.3%) students completed the study. Results/conclusions: Compared with those students who actively participate in exercise, the risk of obesity in college students lacking exercise was 1.25 times higher. Likewise, the probability of failure in the grip strength test and the standing long jump was also higher, with increases of 2.39 fold and 1.39 fold, respectively. Moreover, the total score of physical fitness test was the same. Consequently, this study suggests that college students should exercise regularly to increase their physical fitness.