This study examines the association between work-related insecurity and health, with a focus on how this relationship is moderated by social location (gender, age and race). Drawing on longitudinal data from a Canadian labour market survey (1999-2004) the findings show that certain groups have a higher prevalence of exposure to certain types of work-related insecurity including (among others) low earnings, poor job mobility and the absence of union protection. Results from regression analyses indicate that the negative health impact of work-related insecurity is also unevenly distributed across different social locations. In some cases, older age and visible minority status significantly elevated the health risk posed by work-related insecurity. The implications of these findings are discussed in terms of major shifts in the demographic composition of the labour market due to workforce ageing and the increased participation of women and visible minorities.