Evidence-based Practice Guidelines for Fetal Alcohol Spectrum Disorder (FASD) and Literacy and Learning are derived from an inductive analysis of qualitative data collected in field research. FASD is the umbrella term for a spectrum of neurocognitive and physical disabilities caused by prenatal exposure to alcohol. Data from a sample of N =150 was collected using sharing circles with Aboriginal elders and community members; conversational interviews with parents and their children with FASD; and interviews and focus groups with professionals who support children with FASD and their families. Special protocols were followed in collaboratively planning and participating in research involving Aboriginal communities. Aboriginal research methodologies utilized are situated among emerging, multi-disciplinary, qualitative research methodologies suitable for understanding the complexity of natural phenomena such as FASD. The goal of dissemination is to further translation of research findings regarding evidence-based guidelines for FASD to the clinical or practice levels, across disciplines and sectors, as well as across the life cycle, in order to prevent adverse life outcomes.