Differing from those of their liberal arts and Association of Research Libraries counterparts, today's comprehensive universities face a variety of unique challenges and opportunities when it comes to assessing their collections. This article looks at the different needs and interests of comprehensive universities and focuses on the challenges faced in evaluating collections in three distinct university library settings. Case studies from individual universities will be used to examine issues regarding different means of assessing electronic book collections, collection development policies, and library databases. (Contains 1 figure.)