Undergraduate institutions serve as stepping stones to students' careers. Teaching and learning in science classrooms require quality and integrated teaching-research learning experiences that prepare students to advance their careers. Using publicly available data sets and open-access data analyses software can be impactful for engaging students in meaningful research experiences while keeping institutional expenses associated with implementing and supporting research opportunities low. In this article, we share two examples of student-led data research that utilized open data and software to analyze microbial sequence data. As part of this process, we also recognized the need for discipline-specific databases that can hold a record of publicly available data. Such a setup will support undergraduate educators and students in accessing data relevant to their requirements, thereby narrowing the gap between data availability and accessibility. Finally, both examples illustrate the benefits of using open resources in supporting student learning, with the possibility of using such resources to develop course-based undergraduate research experiences as part of course curricula.