The purpose of this quantitative comparative study was to determine if and to what extent there was a difference between Generation Z and Millennial dental hygiene students' preferred learning styles in Southern California and on social media platforms in the United States. Using the generational theory and the Felder-Soloman Learning Styles Model, this study focused on the preferred learning styles of Generation Z and Millennial dental hygiene students enrolled in dental hygiene programs in Southern California and dental hygiene students on social media platforms in the United States. Using convenience sampling, the Felder-Soloman Index of Learning Styles (ILS) was administered via email recruitment and social media using an online survey tool. A final sample of N = 150 participants were compared on the four dimensions of the ILS: active-reflective, sensing-intuitive, visual-verbal, and sequential-global. Using the independent samples t-test, Millennial dental hygiene students' (n = 61) and Generation Z dental hygiene students' (n = 89) learning styles were compared. There was no significant difference between Millennial and Generation Z dental hygiene students in the active/reflective, sensing/intuitive, or sequential/global dimensions (p > 0.05) with both cohorts indicating a mild preference the active, sensing, and sequential learning style. There was a statistically significant difference in the visual/verbal dimension with Millennials indicating a significantly greater preference for the visual learning style than Generation Z dental hygiene students (p = 0.04). The results of this study have practical implications for improving teaching methodologies and educational practice in dental hygiene education. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://bibliotheek.ehb.be:2222/en-US/products/dissertations/individuals.shtml.]