The purpose of this research brief is to summarize the literature on the career development needs of college students with disabilities, highlight exemplary models of support, and provide recommendations on best practice and future efforts to support positive employment outcomes for persons with disabilities. Four key career development areas are identified: career-related knowledge, work-related experience, job search skills, and disability-related knowledge and self-advocacy. Common themes from the existing literature are synthesized into indicators of evidence-based practice. Models of support at the national, regional, and university-level are reviewed. Recommendations for best practice are provided, as well as future considerations for improving and expanding existing supports. (Contains 1 figure.) [For Volume 2, Issue 2, see ED602378.]