Communicating effectively with parents and carers is an important skill for pre-service teachers to develop. However, they often graduate underprepared due to limited opportunities for parent interaction during their course. When engaging with parents, pre-service teachers must be able to confidently articulate their pedagogical choices, provide examples of what students will do and justify why these choices have been made. One solution lies in providing opportunities for pre-service teachers to practise parent-teacher conferencing using mixed-reality simulation technology. In this study, differentiated instruction served as the context, and reflective practice, teacher self-efficacy theory and experiential learning theory were employed as the theoretical frameworks to build on an existing parent-teacher conferencing model developed by Dotger et al. (2008) to develop a new model for use with pre-service teachers. The model uses mixed-reality simulation technology and incorporates standardised parents and students, peer observation and opportunities for feedback and reflection. The model was developed and trialled with pre-service teachers in a core unit in an initial teacher education course at an Australian university. Results indicated that the pre-service teachers felt more prepared for parent-teacher conferencing after the technology-enhanced role-play experience.