This study examined the risk for alcoholism, diabetes, and depression (triADD) in American Indian/Alaska Native (AI/AN) populations in the U.S. Using the Behavioral Risk Factor Surveillance System, a series of descriptive statistics and regression models were used to examine the interrelationships among these disorders in AI/AN populations. Despite a small sample size, results indicate that AI/ANs are at elevated risk for the individual and combined presence of triADD (OR = 12.5) when compared to the White population. These findings indicate the need for further investigation and prevention focused on effective, culturally appropriate interventions with these populations. (Contains 1 figure and 4 tables.)