Diversity of geography, climate, and culture dictate the nature of the service delivery systems in Alaska, including the provision of prevention programming in substance abuse, alcoholism, health, and behavioral health. Described here are training programs, conferences and symposia, health fairs, and culturally derived interventions that meet the diverse needs of the Native people of Alaska. These interventions operate at the state, local, and regional level with a great deal of attention paid to cooperative and synergistic efforts. Many years of experience with these various programs have led to a body of knowledge that will inform the maintenance of current prevention efforts. Those doing prevention work in the area of health, behavioral health, and alcohol and substance abuse in Alaska should know the context, particularly its rural nature; take time to build relationships and trust; assist community members in finding and developing their own solutions; hire and train local people; design programs around community and family; enable interventions to arise out of Indigenous knowledge and foster choice; introduce Western knowledge in a culturally relevant manner; foster connectivity in training and prevention; and embed prevention efforts within an empowerment paradigm. (Contains 50 references.) (Author/TD)