For the past three decades or so, the field of Science and Technology Studies (STS) has shed light on the interrelationship between modern science and technology, on one side, and contemporary society, on the other. A majority of this knowledge and insights are situated in the context of Western societies, or more precisely, in economically and technologically advanced societies in Western Europe and North America. However, STS has much to offer to the discourse of science and technology in the Global South, a territory characterized by developmental processes. Insights from different schools of thoughts in STS are arguably not only relevant but also applicable to unveil the root cause of problems that many developing societies are facing today. To make this possible, an STS-informed framework is developed to replace the Triple Helix model, which is currently a dominant perspective that prompts how science, technology, and innovation are structurally organized in the developing world. Two steps are taken in this agenda. First, limitations of the Triple Helix are exposed, and second, a new approach drawing on STS concepts is offered as an alternative model that takes into account structural, cultural, and epistemological features of technoscience.